SUPERFOOD)RED

Description

SUPERFOOD)RED nutrient powder supplement contains mixed berry and fruit antioxidant nutrients high in anthocyanins, which are powerful phytonutrients. SUPERFOOD)RED also contains Acai, a recently researched fruit from South America.

Scientists from the United States Department of Agriculture now advise consuming between 3,000 to 5,000 ORAC units (Oxygen Radical Absorption Capacity) each day in order to maintain optimal antioxidant protection in the body’s tissues and plasma. Yet even those who consume five daily servings of typical fruits or vegetables typically only obtain about 2,000 ORAC units each day. (1-2). PANAXEA’S SUPERFOOD)RED contains 3,600 ORAC units per serving.

Acai: This exotic South American fruit is a relatively new addition to the list of “functional foods.” Even at low doses, antioxidants from acai enter human cells and quench dangerous oxygen radicals.6 Studies using freeze-dried acai fruit pulp have shown it to have anti-inflammatory action.6 A laboratory study also demonstrated the power of acai extracts to inhibit the growth and reproduction of leukaemia cells.7

Bilberry: stimulate the increase of protective mucus in the stomach.9 Several laboratory and rodent studies have also shown an effect of anthocyanin-rich bilberry extract against intestinal cancer cells.8,10,11.
In the laboratory, bilberry extract helps up-regulate enzymes that defend against oxidative stress in the eyes, suggesting it may be beneficial for guarding the eyes against age-related disorders, such as macular degeneration.12

Blueberry: These are not only little blue antioxidant powerhouses—wild blueberries are also a modest source of a healthy omega-3 called alpha-linolenic acid.14
Studies suggest that a high-blueberry diet helps protect one of the body’s most important blood vessels—the aorta.15,16 Blueberry is particularly well known for its ability to protect against age-related deterioration of memory and brain function.17-19
Blueberry even displays cancer-protective benefits. In the laboratory, blueberry induced the self-destruction of oral, breast, colon, and prostate cancer cells.13
One study demonstrated the ability of blueberry to prevent bone loss in rats whose ovaries had been removed. These rats no longer produce female hormones, making them a useful animal model for human menopause.5
Blueberries in combination with probiotics have also demonstrated activity against colitis (inflammation of the large intestine)20 and liver injury 21 as well as action against parasites that may be culprits in diarrhea.22

Cranberry: has become famous for its ability to prevent urinary tract infections.23 Scientists believe that cranberry works by preventing infectious Escherichia coli bacteria from adhering to the bladder wall, making it easier for them to be flushed out of the body.24
Cranberry may also help to fight ulcers by preventing Helicobacter pylori, the bacterium implicated in peptic ulcers, from adhering to the stomach wall.25,26.
In the laboratory, cranberry extracts can inhibit the growth and proliferation of breast, prostate, colon, and lung cancer cells.27
Scientists believe that beneficial compounds found in cranberries may help protect cardiovascular health via numerous mechanisms such as modulating blood pressure, inhibiting platelet aggregation, and lessening inflammation.28

Elderberry: Traditionally used against colds and flu, there is indeed laboratory evidence that elderberry is active against the influenza virus. A study in humans showed that an elderberry extract could soothe the symptoms of the flu and shortens the duration of the illness.29
One laboratory study demonstrated that anthocyanins taken from elderberries helped protect blood vessels from free radical damage, suggesting it could be beneficial against cardiovascular disease.3

Pomegranate: A heart-healthy fruit, pomegranate extracts have been shown to help safeguard arterial health. More remarkably, pomegranate juice reduced the presence of arterial plaque in a human study.30 It has also been shown to reduce blood pressure in humans.4
In the laboratory, pomegranate has inhibited the growth of aggressive forms of prostate cancer cells.31 Prostate cancer cells that were injected into mice grew less abundantly if the mice ate a pomegranate extract.31 In both mice and humans with prostate cancer, consuming pomegranate slowed the rising levels of prostate-specific antigen (PSA), which is a marker of disease progression.31,32 Pomegranate has also inhibited growth of colon cancer tumours in both the test tube and in mice 33-35 and inhibited growth of lung36 and breast cancer cells37 in a test tube.
There is even evidence that pomegranate supports the skin’s underlying structure, resulting in younger-looking skin.38

Raspberry/Raspberry Seed: Laboratory studies have demonstrated the ability of raspberry and raspberry seed extracts to inhibit the growth of cancer cells, including oral, breast, prostate, cervical, and colon cancer cells.13,39,40. These little berries may exert their anticancer effects by acting as a rich source of ellagitannins. Present in both the red and black varieties of raspberries, ellagitannins are converted in the body to ellagic acid, 41,42 a well-known cancer-fighting antioxidant.

REFERENCES:

1. Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr. 1998 Nov;68(5):1081-7.
2. Available at: http://www.ars.usda.gov/is/AR/archive/feb99/aging0299.pdf. Accessed July 3, 2008.
3. Bell DR, Gochenaur K. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol. 2006 Apr;100(4):1164-70.
4. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8.33.
5. Devareddy L, Hooshmand S, Collins JK, et al. Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. J Nutr Biochem. 2008 Mar 5.
6. Schauss AG, Wu X, Prior RL, et al. Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem. 2006 Nov 1;54(22):8604-10.
7. Del Pozo-Insfran D, Percival SS, Talcott ST. Acai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells. J Agric Food Chem. 2006 Feb 22;54(4):1222-9.
8. Lala G, Malik M, Zhao C, et al. Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr Cancer. 2006;54(1):84-93.
9. Magistretti MJ, Conti M, Cristoni A. Antiulcer activity of an anthocyanidin from Vaccinium myrtillus. Arzneimittelforschung. 1988 May;38(5):686-90.
10. Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem. 2004 Oct 6;52(20):6122-8. 11. Misikangas M, Pajari AM, Paivarinta E, et al. Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr. 2007 Oct;137(10):2285-90.
12. Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2007 May;48(5):2343-9.
13. Seeram NP, Adams LS, Zhang Y, et al. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem. 2006 Dec 13;54(25):9329-39.
14. Bere E. Wild berries: a good source of omega-3. Eur J Clin Nutr. 2007 Mar;61(3):431-3.
15. Kalea AZ, Lamari FN, Theocharis AD, et al. Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta. J Nutr Biochem. 2006 Feb;17(2):109-16.
16. Norton C, Kalea AZ, Harris PD, Klimis-Zacas DJ. Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat. J Med Food. 2005;8(1):8-13.
17. Andres-Lacueva C, Shukitt-Hale B, Galli RL et al. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci. 2005 Apr;8(2):111-20.
18. Lau FC, Shukitt-Hale B, Joseph JA. The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging. 2005 Dec;26 Suppl 1:128-32.
19. Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph JA. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging. 2007 Aug;28(8):1187-94. 20. Osman N, Adawi D, Ahrne S, Jeppsson B, Molin G. Probiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis. Dig Dis Sci. 2008 Feb 15.
21. Osman N, Adawi D, Ahrne S, Jeppsson B, Molin G. Endotoxin- and D-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry. Dig Liver Dis. 2007 Sep;39(9):849-56.
22. Anthony JP, Fyfe L, Stewart D, McDougall GJ, Smith HV. The effect of blueberry extracts on Giardia duodenalis viability and spontaneous excystation of Cryptosporidium parvum oocysts, in vitro. Methods. 2007 Aug;42(4):339-48.
23. Jepson RG, Craig JC. A systematic review of the evidence for cranberries and blueberries in UTI prevention. Mol Nutr Food Res. 2007 Jun;51(6):738-45.
24. Liu Y, Gallardo-Moreno AM, Pinzon-Arango PA, Reynolds Y, Rodriguez G, Camesano TA. Cranberry changes the physicochemical surface properties of E. coli and adhesion with uroepithelial cells. Colloids Surf B Biointerfaces. 2008 Aug 1;65(1):35-42.
25. Zhang L, Ma J, Pan K, Go VL, Chen J, You WC. Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial. Helicobacter. 2005 Apr;10(2):139-45.
26. Burger O, Weiss E, Sharon N, Tabak M, Neeman I, Ofek I. Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice. Crit Rev Food Sci Nutr. 2002;42(3 Suppl):279-84.
27. Neto CC. Cranberry and its phytochemicals: a review of in vitro anticancer studies. J Nutr. 2007 Jan;137(1 Suppl):186S-93S.
28. McKay DL, Blumberg JB. Cranberries (Vaccinium macrocarpon) and cardiovascular disease risk factors. Nutr Rev. 2007 Nov;65(11):490-502.
29. Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995;1(4):361-9.
30. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33.
31. Malik A, Afaq F, Sarfaraz S et al. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA. 2005 Oct 11;102(41):14813-8.
32. Pantuck AJ, Leppert JT, Zomorodian N, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res. 2006 Jul 1;12(13):4018-26.
33. Kohno H, Suzuki R, Yasui Y, et al. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci. 2004 Jun;95(6):481-6.
34. Adams LS, Seeram NP, Aggarwal BB, et al. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agri Food Chem. 2006 Feb 8;54(3):980-5.
35. Seeram NP, Adams LS, Henning SM, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7.
36. Khan N, Hadi N, Afaq F, et al. Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis. 2007 Jan;28(1):163-73.
37. Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 2002 Feb;71(3):203-17.
38. Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006 Feb 20;103(3):311-8.
39. McDougall GJ, Ross HA, Ikeji M, Stewart D. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J Agric Food Chem. 2008 May 14;56(9):3016-23.
40. Parry J, Su L, Moore J, et al. Chemical compositions, antioxidant capacities, and antiproliferative activities of selected fruit seed flours. J Agric Food Chem. 2006 May 31;54(11):3773-8.
41. Ross HA, McDougall GJ, Stewart D. Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts. Phytochemistry. 2007 Jan;68(2):218-28.
42. Available at: http://www.red-raspberry.org/health/ellagicacid.html. Accessed July 7, 2008.